Types of Biospecimens

National BioService collects biological tissue samples and biofluids for research purposes. Biospecimens are taken from both healthy people and patients with various disorders. Using biological specimens, scientists investigate the mechanisms of disease development, develop new methods for their diagnosis and treatment, and evaluate the efficiency of these methods. All biological materials in our collection fully meet needs of specific biomedical research.

NBS provides the following types of biospecimens for research purposes:


  • Flash-frozen tissue (FF)
  • Formalin-fixed and paraffin embedded tissue (paraffin blocks, FFPE)
  • Unstained slides
  • Stained slides
  • OCT-embedded/frozen tissues
  • Tissue frozen in RNAlater reagent
  • Tissue lysates
  • FFPE block shaves (curls)
  • Unstained and stained sections from OCT-embedded tissues (cryostat cuts) mounted on SuperFrost slides
  • Cryopreserved viable tissue fragments
  • Cryopreserved viable, dissociated cells
  • Cryopreserved viable cells from primary cell cultures
  • Conditioned culture media collected from in vitro cell cultures
  • Cryopreserved viable tumor-infiltrating lymphocytes (TILs)
  • Standard and customized tissue microarrays (ТМА) of design
  • Other


  • Whole blood, bone marrow aspirate, urine, saliva, exudate, wound exudate, ascitic fluid, synovial fluid, etc.
  • Serum
  • Plasma (EDTA, Li-Hep, Na-Hep) separated using the standard method
  • Double-spun plasma and triple-spun plasma (Citrate, Streck, etc.)
  • Flash-frozen saliva samples
  • Saliva samples with DNA stabilizer
  • Flash-frozen urine samples
  • Isolated urine fractions (with cell pellet lysis, flash-freezing, cryopreservation, and supernatant freezing)
  • Frozen whole blood samples
  • Blood smears
  • Peripheral blood samples with DNA and RNA stabilizers
  • Cryopreserved viable peripheral blood mononuclear cells (PBMCs)
  • Flash-frozen (FF) peripheral blood mononuclear cells (PBMCs)
  • Dried blood spots on filter paper
  • Flash-frozen bone marrow aspirate (FF BMA)
  • Bone marrow aspirate smears
  • Cryopreserved viable bone marrow mononuclear cells (BMMCs)
  • Flash-frozen (FF) bone marrow mononuclear cells (BMMCs)
  • Frozen bone marrow aspirate clot samples
  • Bone marrow FFPE blocks
  • Isolated fractions from various other biofluids (exudate, wound exudate, ascitic fluid, synovial fluid, etc.) (with cell pellet lysis, flash-freezing, cryopreservation, and supernatant freezing)
  • Cryopreserved viable cells and flash-frozen cells isolated using MACS technology based on cell surface markers (CD34+, CD133+, CD138+, etc.)
  • Other

Molecular biology

  • RNA from stabilized and flash-frozen tissue samples, with calculation of RIN (RNA integrity number)
  • RNA from stabilized blood samples, with calculation of RIN
  • RNA from stabilized and flash-frozen bone marrow aspirate, with calculation of RIN
  • DNA from various tissues
  • DNA from blood
  • DNA from bone marrow aspirate



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